|Other Names||PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein, Par-4, PAWR, PAR4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.|
|Tissue Location||Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers|
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The tumor suppressor PAWR represses and activates transcription. The protein encoded by this gene is a PAWR protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of PAWR. This protein is specifically upregulated during apoptosis of prostate cells.
charya, M., et al. J. Biol. Chem. 284(50):34829-34838(2009)Zapata-Benavides, P., et al. Arch. Med. Res. 40(7):595-599(2009)Fernandez-Marcos, P.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(31):12962-12967(2009)Burikhanov, R., et al. Cell 138(2):377-388(2009)Lee, J.W., et al. Cancer Lett. 279(2):193-201(2009)Guo, Q., et al. J. Biol. Chem. 276(19):16040-16044(2001)
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