|Other Names||Bombesin receptor subtype-3, BRS-3, BRS3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||In germ cells in testis. Lung carcinoma cells.|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian bombesin-like peptides (see MIM 137260) are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor (MIM 305670), neuromedin B receptor (MIM 162341), and bombesin-like receptor-3 (BRS3) (Ohki-Hamazaki et al., 1997).
??ang, Y., et al. Cell Biol. Int. 31(12):1495-1500(2007)??an, Y.R., et al. Biochem. J. 405(1):131-137(2007)??ou, X., et al. Lung Cancer 54(2):143-148(2006)??oss, M.T., et al. Nature 434(7031):325-337(2005)??iu, J., et al. Biochemistry 41(28):8954-8960(2002)
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