|Other Names||Gamma-interferon-inducible lysosomal thiol reductase, 18--, Gamma-interferon-inducible protein IP-30, Legumaturain, IFI30, GILT, IP30|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).|
|Cellular Location||Secreted. Lysosome.|
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Provided below are standard protocols that you may find useful for product applications.
IFI30 cleaves disulfide bonds in proteins by reduction. May facilitate the complete unfolding of proteins destined for lysosomal degradation. It may be involved in MHC class II-restricted antigen processing.
Imami K., et.al., Anal. Sci. 24:161-166(2008).
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