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RAB3IP Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96QF0 |
|---|
| Gene ID | 117177 |
|---|---|
| Other Names | Rab-3A-interacting protein, Rab3A-interacting protein, Rabin-3, SSX2-interacting protein, RAB3IP {ECO:0000312|EMBL:CAC598361}, RABIN8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAB3IP {ECO:0000312|EMBL:CAC59836.1} |
|---|---|
| Synonyms | RABIN8 |
| Function | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:31204173, PubMed:25673879). |
| Cellular Location | Cytoplasm. Nucleus Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. |
| Tissue Location | Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown. It belongs to the SEC2 family and may be involved in protein transport. It is predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. There are 8 isoforms produced by alternative splicing.
References
??enkatesan, K., et al. Nat. Methods 6(1):83-90(2009)??attula, K., et al. Mol. Biol. Cell 13(9):3268-3280(2002)??e Bruijn, D.R., et al. Genes Chromosomes Cancer 34(3):285-298(2002)??ischer, U., et al. Int. J. Oncol. 20(1):173-176(2002)??rondyk, W.H., et al. Mol. Cell. Biol. 15(3):1137-1143(1995)
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