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ZNF451 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y4E5
Peptide ID 91102021
Additional Information
Gene ID 26036
Other Names Zinc finger protein 451, Coactivator for steroid receptors, ZNF451, COASTER, KIAA0576, KIAA1702
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF451
Synonyms COASTER {ECO:0000303|Ref.1}, KIAA0576, K
Function E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300- mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).
Cellular Location Nucleus. Nucleus, PML body. Nucleus, nucleoplasm Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location.
Research Areas
Citations (0)

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ZNF451 may be involved in transcriptional regulation. Coactivator for steroid receptors


Karvonen, U., et al. J. Mol. Biol. 382(3):585-600(2008)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)

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$ 80.00
Cat# BP9637a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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