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CARD11 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BXL7
Peptide ID 90904009
Additional Information
Gene ID 84433
Other Names Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, Carma 1, CARD11, CARMA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARD11
Synonyms CARMA1
Function Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Cellular Location Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Tissue Location Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells
Research Areas
Citations (0)

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CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.


Davila, S., et al. Genes Immun. (2010) Brenner, D., et al. Proc. Natl. Acad. Sci. U.S.A. 106(34):14508-14513(2009)Welteke, V., et al. EMBO Rep. 10(6):642-648(2009)

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$ 80.00
Cat# BP9705b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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