VAV2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P52735 |
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Gene ID | 7410 |
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Other Names | Guanine nucleotide exchange factor VAV2, VAV-2, VAV2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | VAV2 |
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Function | Guanine nucleotide exchange factor for the Rho family of Ras- related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). |
Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.
References
Duan, L., et al. J. Biol. Chem. 285(2):1555-1568(2010)Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Holthusen, K., et al. Am J Ther 16(6):496-507(2009)
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