|Other Names||Pleckstrin homology domain-containing family H member 2, PLEKHH2, KIAA2028|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K|
|Tissue Location||Kidney. Reduced expression in patients with focal segmental glomerulosclerosis.|
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Provided below are standard protocols that you may find useful for product applications.
Greene, C.N., et al. Hum. Genet. 124(3):255-262(2008)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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