|Other Names||SEC14-like protein 1, SEC14L1, SEC14L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).|
|Cellular Location||Cytoplasm. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Kalikin, L.M., et al. Mamm. Genome 12(12):925-929(2001)Chinen, K., et al. Cytogenet. Cell Genet. 73(3):218-223(1996)
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