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DFFB Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O76075
Additional Information
Gene ID 1677
Other Names DNA fragmentation factor subunit beta, 3---, Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, Caspase-activated nuclease, CPAN, DNA fragmentation factor 40 kDa subunit, DFF-40, DFFB, CAD, DFF2, DFF40
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DFFB
Synonyms CAD, DFF2, DFF40
Function Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)
citation

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Background

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.

References

Hanus, J., et al. Apoptosis 13(3):377-382(2008)Kalinowska-Herok, M., et al. Acta Biochim. Pol. 55(1):21-26(2008)Neimanis, S., et al. J. Biol. Chem. 282(49):35821-35830(2007)Hristoskova, S., et al. J. Cell. Physiol. 213(2):490-494(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)

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$ 277.78
Cat# BP9841a
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