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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NFM4 |
|---|---|
| Peptide ID | 90819057 |
| Gene ID | 196883 |
|---|---|
| Other Names | Adenylate cyclase type 4, ATP pyrophosphate-lyase 4, Adenylate cyclase type IV, Adenylyl cyclase 4, ADCY4 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADCY4 |
|---|---|
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm |
| Tissue Location | Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals.
References
Rhim, J.H., et al. Aging Cell 5(6):451-461(2006)Jiang, G., et al. Am. J. Physiol. Endocrinol. Metab. 284 (4), E671-E678 (2003) Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)Ludwig, M.G., et al. J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002) Cote, M., et al. J. Clin. Endocrinol. Metab. 86(9):4495-4503(2001)
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