|Other Names||F-box/LRR-repeat protein 7, F-box and leucine-rich repeat protein 7, F-box protein FBL6/FBL7, FBXL7, FBL6, FBL7, KIAA0840|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FBL6, FBL7, KIAA0840|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome during spindle formation.|
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.
Venables, J.P., et al. Hum. Mol. Genet. 14(16):2289-2303(2005)Watanabe, N., et al. Proc. Natl. Acad. Sci. U.S.A. 101(13):4419-4424(2004)Ilyin, G.P., et al. Genomics 67(1):40-47(2000)
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