|Other Names||Mitochondrial dicarboxylate carrier, Solute carrier family 25 member 10, SLC25A10, DIC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed|
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Provided below are standard protocols that you may find useful for product applications.
The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Khanna, H., et al. J. Biol. Chem. 280(39):33580-33587(2005)Mizuarai, S., et al. J. Biol. Chem. 280(37):32434-32441(2005)
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