|Other Names||Probable ATP-dependent RNA helicase DDX6, ATP-dependent RNA helicase p54, DEAD box protein 6, Oncogene RCK, DDX6, HLR2, RCK|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).|
|Cellular Location||Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules (PubMed:26184334)|
|Tissue Location||Abundantly expressed in most tissues.|
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This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing.
Broytman, O., et al. Neurobiol. Aging 30(12):1962-1974(2009)Han, J.W., et al. Nat. Genet. 41(11):1234-1237(2009)Minshall, N., et al. Mol. Biol. Cell 20(9):2464-2472(2009)Tritschler, F., et al. Mol. Cell 33(5):661-668(2009)
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