|Other Names||DNA polymerase lambda, Pol Lambda, 4299-, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa, POLL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|
|Tissue Location||Expressed in a number of tissues. Abundant in testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes.
Brown, J.A., et al. J. Mol. Biol. 395(2):282-290(2010)van Loon, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(43):18201-18206(2009)Garcia-Diaz, M., et al. Nat. Struct. Mol. Biol. 16(9):967-972(2009)
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