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SNX27 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96L92
Peptide ID 91102259
Additional Information
Gene ID 81609
Other Names Sorting nexin-27, SNX27, KIAA0488
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNX27
Synonyms KIAA0488
Function Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Cellular Location Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products
Tissue Location Widely expressed. Expressed in cells of hematopoietic origin (at protein level)
Research Areas
Citations (0)

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SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.


Lunn, M.L., et al. Nat. Neurosci. 10(10):1249-1259(2007)Nassirpour, R., et al. Channels (Austin) 1(5):331-333(2007)MacNeil, A.J., et al. Biochem. Biophys. Res. Commun. 359(4):848-853(2007)Rincon, E., et al. Mol. Cell Proteomics 6(6):1073-1087(2007)

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$ 80.00
Cat# BP9947c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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