|Other Names||Sulfatase-modifying factor 1, 1899-, C-alpha-formylglycine-generating enzyme 1, SUMF1, FGE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart|
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Provided below are standard protocols that you may find useful for product applications.
SUMF1 encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine.
Oshikawa, M., et al. Mol. Vis. 15, 482-494 (2009) Fraldi, A., et al. Hum. Mol. Genet. 17(17):2610-2621(2008)Hara, K., et al. Neurology 71(8):547-551(2008)Yis, U., et al. Brain Dev. 30(5):374-377(2008)
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