|Other Names||Filamin-A-interacting protein 1, FILIP, FILIP1, KIAA1275|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.|
|Cellular Location||Cytoplasm, cytoskeleton|
|Tissue Location||Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
FLIP1 acts through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. FLIP1 may be able to induce the degradation of filamin-A.
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Nagano, T., et al. Nat. Cell Biol. 4(7):495-501(2002)
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