|Calculated MW||44552 Da|
|Other Names||Cathepsin D|
|Application Notes||Reconstitute the vial in H₂O to a concentration of 0.1-1 µg/ µl. Aliquot and refreeze at -80°C immediately for future use.|
|Storage||-80°C; Lyophilized from a solution containing 2 mM sodium phosphate, pH 6.5|
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Provided below are standard protocols that you may find useful for product applications.
Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers.
Faust P.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985).
Westley B.R.,et al.Nucleic Acids Res. 15:3773-3786(1987).
Redecker B.,et al.DNA Cell Biol. 10:423-431(1991).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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