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Caspase-2, human recombinant protein


Product info
Primary Accession P42575
Calculated MW two large (19 kDa) and two small (12 kDa) subunits
Additional Info
Gene ID 835
Gene Symbol CASP2
Other Names Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity Caspase-2
Application Notes Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Format Lyophilized powder
Storage -70°C; Lyophilized powder
Citations (0)

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Caspase-2 (also know as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed active caspase-2 is a heterotetramer consisting of two large (19 kDa) and two small (12 kDa) subunits.The recombinant active human caspase-2 was expressed in E. coli. The active caspase-2 preferentially cleaves caspase-2 substrates (e.g., VDVAD-AFC or VDVAD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-VDVAD-pNA or Ac-VDVAD-AFC


Wang L.,et al.Cell 78:739-750(1994).
Droin N.,et al.Cancer Res. 60:7039-7047(2000).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).

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$ 305.00
$ 175.00
Cat# PBV10011r
(40 western blots)
Availability: 5-7days
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