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Active Porcine Calpain 1 recombinant protein

Calpain 1

Product info
Primary Accession P35750
Calculated MW 110 kDa
Additional Info
Gene ID 397027
Gene Symbol CAPN1
Other Names Calpain-1 catalytic subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain
Gene Source Porcine
Source Porcine Erythrocytes
Assay&Purity SDS-PAGE; ≥85%
Assay2&Purity2 HPLC;
Recombinant No
Results ≥ 1000 units/mg
Target/Specificity Calpain 1
Format Liquid
Storage -70°C; In 20 mM imidazole-HCl, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
Citations (0)

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The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (n-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.


Smith T.P.L.,et al.J. Anim. Sci. 79:552-553(2001).
Winteroe A.K.,et al.Mamm. Genome 7:509-517(1996).
Sun W.,et al.Biochimie 75:931-936(1993).

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$ 295.00
Cat# PBV10026r
(40 western blots)
Availability: 5-7days
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