|Calculated MW||110 kDa|
|Other Names||Calpain-1 catalytic subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Micromolar-calpain|
|Results||≥ 1000 units/mg|
|Storage||-70°C; In 20 mM imidazole-HCl, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.|
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Provided below are standard protocols that you may find useful for product applications.
The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (n-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.
Smith T.P.L.,et al.J. Anim. Sci. 79:552-553(2001).
Winteroe A.K.,et al.Mamm. Genome 7:509-517(1996).
Sun W.,et al.Biochimie 75:931-936(1993).
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