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TRIM71 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q2Q1W2 |
|---|---|
| Gene ID | 131405 |
| Calculated MW | 93385 Da |
| Gene ID | 131405 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of TRIM71. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | E3 ubiquitin-protein ligase TRIM71, 6.3.2.-, Protein lin-41 homolog, Tripartite motif-containing protein 71, TRIM71, LIN41 |
| Target/Specificity | TRIM71 |
| Formulation | 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | TRIM71 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM71 (HGNC:32669) |
|---|---|
| Synonyms | LIN41 |
| Function | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). |
| Cellular Location | Cytoplasm, P-body |
| Tissue Location | Specifically expressed in testis. |
Research Areas
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