|Calculated MW||284597 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of α-Fodrin. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Sptan1, Spna2, Spta2|
|Formulation||50 µg (0.5 mg/ml) α-Fodrin peptide in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||alpha-Fodrin Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.|
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