Bcl-3 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P20749 |
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Gene ID | 602 |
Calculated MW | 47584 Da |
Gene ID | 602 |
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Application & Usage | The peptide is used for blocking the antibody activity of Bcl-3. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | B-cell lymphoma 3 protein, BCL-3, Proto-oncogene BCL3, BCL3, BCL4, D19S37 |
Target/Specificity | Bcl-3 |
Formulation | 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Bcl-3 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BCL3 |
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Synonyms | BCL4, D19S37 |
Function | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). |
Cellular Location | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys-63'- linked ubiquitin chains is required for nuclear accumulation |
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