|Calculated MW||47584 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of Bcl-3. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||B-cell lymphoma 3 protein, BCL-3, Proto-oncogene BCL3, BCL3, BCL4, D19S37|
|Formulation||50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||Bcl-3 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation|
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