Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Proteins   >   ProNT-3, human recombinant protein   

ProNT-3, human recombinant protein

HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor

Product info
Primary Accession P20783
Calculated MW 27.4 kDa
Additional Info
Gene ID 4908
Gene Symbol NTF3
Other Names Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC; ≥95%
Recombinant Yes
Sequence Recombinant Human ProNT-3 is produced with E.coli expression system. Target protein is expressed with sequence (Asn19-Thr257) of Human (Uniprot #P20783).The sequence of the first five N-terminal amino acids was determined and was found to be Asn-Asn-Met-Asp-Gln.
Target/Specificity ProNT-3
Application Notes Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 µg/ml.). This can further be diluted to other aqueous buffers.
Format Lyophilized protein
Storage -20°C; Lyophilized from a 0.2 µm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2.
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


Proneurotrophin-3 (ProNT-3) is the precursor form of neurotrophin 3. ProNT3 functions via p75NTR and sortilin and induces neuronal apoptosis. On the contrary, mature NT3 interacts with Trk receptors and selectively promotes the survival, growth and differentiation of neurons. As axon retrograde transport is crucial for neurotrophin signaling, Pro-NT3 also plays an important role in the mechanism of retrograde signaling. ProNT3 interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-NT3 plays an important role in retrograde signaling mechanism.


Kaisho Y.,et al.FEBS Lett. 266:187-191(1990).
Rosenthal A.,et al.Neuron 4:767-773(1990).
Jones K.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990).
Maisonpierre P.C.,et al.Genomics 10:558-568(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

$ 165.00
$ 475.00
$ 3,800.00
Cat# PBV10203r
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanKoreaLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Santa Cruz Alternative
Terms & Conditions