|Calculated MW||39183 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of HDAC-11. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C.|
|Other Names||Histone deacetylase 11, HD11, 188.8.131.52, HDAC11|
|Formulation||50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% sodium azide.|
|Reconstitution & Storage||-20 °C|
|Precautions||HDAC-11 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|
|Cellular Location||Nucleus. Note=Predominantly nuclear.|
|Tissue Location||Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis|
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