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GDF-15, human recombinant protein

MIC1, PDF, PLAB, PTGFB

     
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product info
Primary Accession Q99988
Calculated MW 26.8 kDa
Additional Info
Gene ID 9518
Gene Symbol GDF-15
Other Names Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Results 1-2 µg/ml
Sequence MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI
Target/Specificity GDF-15
Application Notes Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 5 mM acetic acid at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Format Lyophilized protein
Storage -20°C; Sterile filtered and lyophilized with no additives
Citations (0)

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Background

Growth and differentiation factor 15 (GDF-15) is a TGFβ family member, made by in the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an immerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure. Recombinant human GDF-15 is a non-glycosylated, disulfide linked homodimer. It is comprised of two identical 120 amino acid monomers and has a total molecular mass of 26.8 kDa.

References

Hromas R.,et al.Biochim. Biophys. Acta 1354:40-44(1997).
Yokoyama-Kobayashi M.,et al.J. Biochem. 122:622-626(1997).
Bootcov M.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11514-11519(1997).
Paralkar V.M.,et al.J. Biol. Chem. 273:13760-13767(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 190.00
$ 475.00
$ 4,200.00
Cat# PBV10309r-20
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