|Calculated MW||70642 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of active HAT-2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C|
|Other Names||Histone acetyltransferase KAT7, 18.104.22.168, Histone acetyltransferase binding to ORC1, Lysine acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, MYST-2, KAT7, HBO1, HBOa, MYST2|
|Formulation||50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||HAT-2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HBO1, HBOa, MYST2|
|Function||Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.|
|Cellular Location||Nucleus, nucleoplasm|
|Tissue Location||Ubiquitously expressed, with highest levels in testis.|
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