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MAP-1 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9ERH6 |
|---|---|
| Gene ID | 64113 |
| Calculated MW | 39404 Da |
| Gene ID | 64113 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of active MAP-1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C |
| Other Names | Modulator of apoptosis 1, MAP-1, Moap1 |
| Target/Specificity | MAP-1 |
| Formulation | 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | MAP-1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Moap1 {ECO:0000303|PubMed:34413232, ECO:0000312|MGI:MGI:1915555} |
|---|---|
| Function | Retrotransposon-derived protein that forms virion-like capsids (PubMed:34413232). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (By similarity). Required for death receptor-dependent apoptosis (By similarity). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (By similarity). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96BY2}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96BY2}. Extracellular vesicle membrane. Note=Forms virion-like extracellular vesicles that are released from cells. |
| Tissue Location | Widely expressed, including in the brain. High expression levels in testis. |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# PBV10319b-50
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