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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Dicer Blocking Peptide   

Dicer Blocking Peptide

Product Information
Primary Accession Q9UPY3
Gene ID 23405
Calculated MW 218682 Da
Additional Information
Gene ID 23405
Application & Usage The peptide is used for blocking the antibody activity of active Dicer. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C
Other Names Endoribonuclease Dicer,, Helicase with RNase motif, Helicase MOI, DICER1, DICER, HERNA, KIAA0928
Target/Specificity Dicer
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsDicer Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DICER, HERNA, KIAA0928
Function Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Cellular Location Cytoplasm.
Research Areas
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$ 95.00
Cat# PBV10322b
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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