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LRP-5/6 Blocking Peptide

Product Information
Primary Accession O75197
Gene ID 4041
Calculated MW 179145 Da
Additional Information
Gene ID 4041
Application & Usage The peptide is used for blocking the antibody activity of LRP-5/6. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C
Other Names Low-density lipoprotein receptor-related protein 5, LRP-5, LRP5, LR3, LRP7
Target/Specificity LRP-5/6
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsLRP-5/6 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRP5
Synonyms LR3, LRP7
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Cellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=Chaperoned to the plasma membrane by MESD.
Tissue Location Widely expressed, with the highest level of expression in the liver and in aorta
Research Areas
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$ 95.00
Cat# PBV10337b
(40 western blots)
Availability: 5-7days
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