|Calculated MW||40444 Da|
|Other Names||Vascular Endothelial Growth Factor-D, FIGF, c-Fos-induced growth factor|
|Application Notes||Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.|
|Storage||-20°C; Lyophilized without additives|
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Provided below are standard protocols that you may find useful for product applications.
VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. Recombinant VEGF-D was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.
Yamada Y.,et al.Genomics 42:483-488(1997).
Rocchigiani M.,et al.Genomics 47:207-216(1998).
Achen M.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:548-553(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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