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Noggin, human recombinant protein


Product info
Primary Accession Q13253
Calculated MW 23.1 kDa
Additional Info
Gene ID 9241
Gene Symbol NOG
Other Names NOG
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC; ≥95%
Recombinant Yes
Results 0.05-0.08 µg/ml
Application Notes Reconstitute in H₂O to a concentration of 0.1 to 1.0 mg/ml. Note: Due to solubility reasons the protein should be kept at low pH. This solution can then be diluted into other aqueous buffers
Format Lyophilized protein
Storage -20°C; Sterile filtered and lyophilized with no additives
Citations (0)

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Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 23.1 kDa non-disulfide-linked homodimer consisting of a total of 206 amino acid residues.

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$ 595.00
$ 3,600.00
$ 195.00
Cat# PBV10350r
(40 western blots)
Availability: 5-7days
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