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CCR4 Blocking Peptide
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- BACKGROUND
| Primary Accession | P51679 |
|---|---|
| Other Accession | 232680 |
| Gene ID | 1233 |
| Calculated MW | 41403 Da |
| Gene ID | 1233 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of CCR4. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5, CD194, CCR4, CMKBR4 |
| Target/Specificity | CCR4 |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | CCR4 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCR4 |
|---|---|
| Synonyms | CMKBR4 |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells (PubMed:10754297). |
Research Areas
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Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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