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Sox1 Blocking Peptide

     
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Product Information
Primary Accession P53783
Gene ID 20664
Additional Information
Application & Usage The peptide is used for blocking the antibody activity of Sox-1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Transcription factor SOX-1, Sox1, Sox-1
Target/Specificity Sox1
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSox1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sox1
Synonyms Sox-1
Function Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus.
Tissue Location Mainly in the developing central nervous system. Expressed in developing urogenital ridge EMBL; X94126; CAA63846.1; -; Genomic_DNA EMBL; AB108672; BAC75667.1; -; mRNA EMBL; AC102525; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS57605.1; - PIR; S10950; S10950 RefSeq; NP_033259.2; NM_009233.3 UniGene; Mm.39088; - ProteinModelPortal; P53783; - SMR; P53783; - BioGrid; 203396; 1 STRING; 10090.ENSMUSP00000137203; - iPTMnet; P53783; - PhosphoSitePlus; P53783; - PaxDb; P53783; - PeptideAtlas; P53783; - PRIDE; P53783; - Ensembl; ENSMUST00000180353; ENSMUSP00000137203; ENSMUSG00000096014 GeneID; 20664; - KEGG; mmu:20664; - UCSC; uc009kwa.2; mouse CTD; 6656; - MGI; MGI:98357; Sox1 eggNOG; ENOG410IPZ0; Eukaryota eggNOG; ENOG41102MY; LUCA GeneTree; ENSGT00760000118988; - HOGENOM; HOG000231647; - HOVERGEN; HBG105663; - InParanoid; P53783; - KO; K09267; - OMA; HSRGPCP; - OrthoDB; EOG091G0F15; - TreeFam; TF351735; - PRO; PR:P53783; - Proteomes; UP000000589; Chromosome 8 Bgee; ENSMUSG00000096014; - CleanEx; MM_SOX1; - Genevisible; P53783; MM GO; GO:0005634; C:nucleus; IDA:MGI GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISO:MGI GO; GO:0003677; F:DNA binding; IDA:MGI GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:NTNU_SB GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IDA:MGI GO; GO:0030900; P:forebrain development; IMP:MGI GO; GO:0021884; P:forebrain neuron development; IMP:MGI GO; GO:0021879; P:forebrain neuron differentiation; IMP:MGI GO; GO:0002089; P:lens morphogenesis in camera-type eye; IMP:MGI GO; GO:0001764; P:neuron migration; IMP:MGI GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB GO; GO:0021521; P:ventral spinal cord interneuron specification; IMP:MGI Gene3D; 1.10.30.10; -; 1 InterPro; IPR009071; HMG_box_dom InterPro; IPR036910; HMG_box_dom_sf InterPro; IPR031268; SOX-1 InterPro; IPR022097; SOX_fam PANTHER; PTHR10270:SF40; PTHR10270:SF40; 1 Pfam; PF00505; HMG_box; 1 Pfam; PF12336; SOXp; 1 SMART; SM00398; HMG; 1 SUPFAM; SSF47095; SSF47095; 1 PROSITE; PS50118; HMG_BOX_2; 1 2: Evidence at transcript level; Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 391 Transcription factor SOX-1 /FTId=PRO_0000048713 DNA_BIND 51 119 HMG box. {ECO:0000255|PROSITE- ProRule:PRU00267} COMPBIAS 30 43 Poly-Gly COMPBIAS 145 150 Poly-Gly COMPBIAS 197 204 Poly-Ala COMPBIAS 280 288 Poly-Ala COMPBIAS 296 306 Poly-Ala COMPBIAS 357 364 Poly-Ala CONFLICT 29 29 G -> R (in Ref. 1; CAA63846) CONFLICT 222 222 A -> R (in Ref. 1; CAA63846) SEQUENCE 391 AA; 39053 MW; EA88F7C49E30BDA8 CRC64; MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGTKANQDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG YAHVNGWANG AYPGSVAAAA AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP HNPQPMHRYD MGALQYSPIS NSQGYMSASP SGYGGIPYGA AAAAAAAAGG AHQNSAVAAA AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA GEGGDPAAAA AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I
Research Areas
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$ 95.00
Cat# PBV10372b-50
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