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IGF-BP3, human recombinant protein

Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein

Product info
Primary Accession P17936
Calculated MW 28.8 kDa
Additional Info
Gene ID 3486
Gene Symbol IBP3
Other Names Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC; ≥98%
Recombinant Yes
Results <0.2 mg/ml
Application Notes Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
Format Lyophilized protein
Storage -20°C; Sterile filtered and lyophilized from 20 mM HCl
Citations (0)

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Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.


Wood W.I.,et al.Mol. Endocrinol. 2:1176-1185(1988).
Cubbage M.L.,et al.J. Biol. Chem. 265:12642-12649(1990).
Thweatt R.,et al.DNA Seq. 4:43-46(1993).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).

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$ 525.00
$ 2,850.00
$ 190.00
Cat# PBV10375r
(40 western blots)
Availability: 5-7days
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