IGF-BP3, human recombinant protein
Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein
|Calculated MW||28.8 kDa|
|Other Names||Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein|
|Sequence||AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS|
|Application Notes||Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.|
|Storage||-20°C; Sterile filtered and lyophilized from 20 mM HCl|
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Provided below are standard protocols that you may find useful for product applications.
Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
Wood W.I.,et al.Mol. Endocrinol. 2:1176-1185(1988).
Cubbage M.L.,et al.J. Biol. Chem. 265:12642-12649(1990).
Thweatt R.,et al.DNA Seq. 4:43-46(1993).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
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