|Calculated MW||86402 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of Mitofusin 2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Mitofusin-2, 3.6.5.-, Transmembrane GTPase MFN2, MFN2, CPRP1, KIAA0214|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||Mitofusin 2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.|
|Cellular Location||Mitochondrion outer membrane; Multi- pass membrane protein. Note=Colocalizes with BAX during apoptosis|
|Tissue Location||Ubiquitous; expressed at low level. Highly expressed in heart and kidney.|
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