|Calculated MW||180 kDa in reducing gel|
|Other Names||Thrombospondin-1, THBS1, TSP, TSP1, THBS, THBS-1|
|Source||Baculovirus (Sf9 insect cells)|
|Application Notes||Reconstitute with water at the concentration 0.1 mg/ml.|
|Storage||-20°C; Lyophilized from 20 mM sodium phosphate, pH 6.0, 300 mM NaCl and 0.1% BSA.|
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Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been used as a potential regulator of tumor growth and metastasis. TSP expression is highly regulated by different hormones and cytokines and is developmentally controlled. TSP stimulates the growth of Vascular smooth muscle cells and human foreskin fibroblasts, a combination of IFN-γ and TNF-α inhibits TSP production in these cells. Recombinant Human Thrombospondin is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. Human Thrombospondin is purified by proprietary chromatographic techniques.
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