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PINK1 Blocking Peptide

Product Information
Primary Accession Q99MQ3
Other Accession EDL13261
Gene ID 68943
Calculated MW 63181 Da
Additional Information
Gene ID 68943
Application & Usage The peptide is used for blocking the antibody activity of PINK1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.

Other Names Serine/threonine-protein kinase PINK1, mitochondrial,, BRPK, PTEN-induced putative kinase protein 1, Pink1
Target/Specificity PINK1
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPINK1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pink1
Function Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24784582).
Cellular Location Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9BXM7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9BXM7}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BXM7}
Tissue Location High levels expressed in testis, lower levels in brain, heart, lung, liver and kidney
Research Areas
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$ 95.00
Cat# PBV10442b
(40 western blots)
Availability: 5-7days
Bulk Size
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