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Heat Shock Protein 70, human recombinant protein

Human Heat Shock Protein 70, Heat Shock Protein 70

Product info
Primary Accession P08107
Calculated MW 70.0 kDa
Additional Info
Gene ID 3303
Gene Symbol HSPA1A/1B
Other Names Human Heat Shock Protein 70, Heat Shock Protein 70
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC; ≥98%
Recombinant Yes
Application Notes Reconstitute in H₂O (solubility > 40 mg/ml), aliquot and store at -80 °C
Format Lyophilized protein
Storage -20°C; Lyophilized from 41 mM Tris, pH 8 containing 81 mM NaCl.
Citations (0)

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HSP70 and HSP90 are molecular chaperones expressed constitutively under normal conditions to maintain protein homeostasis and are induced upon environmental stress. Both HSP70 and HSP90 are able to interact with unfolded proteins to prevent irreversible aggregation and catalyze the refolding of their substrates in an ATP- and co-chaperone-dependent manner. HSP70 has a broad range of substrates including newly synthesized and denatured proteins, while HSP90 tends to have a more limited subset of substrates, most of which are signaling molecules. HSP70 and HSP90 often function collaboratively in a multi-chaperone system, which requires a minimal set of co-chaperones: HSP40, Hop, and p23. The co-chaperones either regulate the intrinsic ATPase activity of the chaperones or recruit chaperones to specific substrates or subcellular compartments. When the ubiquitin ligase CHIP associates with the HSP70/HSP90 complex as a cofactor, the unfolded substrates are subjected to degradation by the proteasome. The biological functions of HSP70/HSP90 extend beyond their chaperone activity. They are essential for the maturation and inactivation of nuclear hormones and other signaling molecules. They also play a role in vesicle formation and protein trafficking.


Milner C.M.,et al.Immunogenetics 32:242-251(1990).
Hunt C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6455-6459(1985).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 765.00
$ 4,950.00
$ 275.00
Cat# PBV10448r
(40 western blots)
Availability: 5-7days
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