|Calculated MW||53154 Da|
|Other Names||Angiotensin, Angiotensin II|
|Storage||-20°C; Lyophilized powder|
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Provided below are standard protocols that you may find useful for product applications.
The octapeptide angiotensin II exerts a wide range of effects on the cardioVascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Angiotensin II is formed by cleavage of angiotensin I by angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.
Kageyama R.,et al.Biochemistry 23:3603-3609(1984).
Gaillard I.,et al.DNA 8:87-99(1989).
Fukamizu A.,et al.J. Biol. Chem. 265:7576-7582(1990).
Kunapuli S.P.,et al.Circ. Res. 60:786-790(1987).
Kunapuli S.P.,et al.Arch. Biochem. Biophys. 254:642-646(1987).
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