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TXNRD1 Blocking Peptide

     
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Product Information
Primary Accession Q16881
Gene ID 5743
Calculated MW 70906 Da
Additional Information
Gene ID 7296
Application & Usage The peptide is used for blocking the antibody activity of TXNRD1 (Cat. No. 7005-100). It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Thioredoxin reductase 1, cytoplasmic, TR, 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF
Target/Specificity TNXRD1
Formulation 50 µg (0.5 mg/ml) in PBS (pH 7.2) with 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTXNRD1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNRD1
Synonyms GRIM12, KDRF
Function Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Cellular Location Cytoplasm. Isoform 5: Cytoplasm.
Tissue Location Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver
Research Areas
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$ 95.00
Cat# PBV10517b-50
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