TXNRD1 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q16881 |
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Gene ID | 5743 |
Calculated MW | 70906 Da |
Gene ID | 7296 |
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Application & Usage | The peptide is used for blocking the antibody activity of TXNRD1 (Cat. No. 7005-100). It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Thioredoxin reductase 1, cytoplasmic, TR, 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF |
Target/Specificity | TNXRD1 |
Formulation | 50 µg (0.5 mg/ml) in PBS (pH 7.2) with 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | TXNRD1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TXNRD1 (HGNC:12437) |
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Synonyms | GRIM12, KDRF |
Function | Reduces disulfideprotein thioredoxin (Trx) to its dithiol- containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). |
Cellular Location | [Isoform 1]: Cytoplasm [Isoform 5]: Cytoplasm |
Tissue Location | [Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines |
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