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Mouse recombinant protein DHFR

Mouse Recombinant DHFR

     
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Product info
Primary Accession P00375
Concentration 1
Calculated MW 23.8 kDa (207 aa, 1-187 aa + NT His-Tag)
Additional Info
Gene ID 13361
Gene Symbol DHFR
Other Names Dihydrofolate reductase.
Gene Source Mouse
Source E. Coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results >0.2 units/mg
Sequence MGSSHHHHHH SSGLVPRGSH MVRPLNCIVA VSQNMGIGKN GDLPWPPLRN EFKYFQRMTT TSSVEGKQNL VIMGRKTWFS IPEKNRPLKD RINIVLSREL KEPPRGAHFL AKSLDDALRL IEQPELASKV DMVWIVGGSS VYQEAMNQPG HLRLFVTRIM QEFESDTFFP EIDLGKYKLL PEYPGVLSEV QEEKGIKYKF EVYEKKD
Format Liquid
Storage -80°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 2 mM DTT and 10% glycerol.
Citations (0)

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Background

Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and it is essential for the synthesis of thymidylate, purines and several amino acids. Expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.

References

Crouse G.F.,et al.J. Biol. Chem. 257:7887-7897(1982).
Simonsen C.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:2495-2499(1983).
McIvor R.S.,et al.Nucleic Acids Res. 18:7025-7032(1990).
Stone D.,et al.J. Biol. Chem. 254:480-488(1979).
McGrogan M.,et al.J. Biol. Chem. 260:2307-2314(1985).

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$ 340.00
Cat# PBV10619r-100
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