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Human recombinant protein Glyoxalase I

Human Recombinant Glyoxalase I

     
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  • CITATIONS
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  • BACKGROUND
Product info
Primary Accession Q04760
Concentration 1
Calculated MW 20.7 kDa (184 aa, 1-184 aa)
Additional Info
Gene ID 2739
Gene Symbol GLO1
Other Names Lactoylglutathione lyase, Glx 1, GLO-1 Methylglyoxalase, Aldoketomutase
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results >0.4 units/mg
Sequence MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM
Format Liquid
Storage -80°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
Citations (0)

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Background

GLO1 is involved in the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutathione. GLO1 is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. GLO1 enzyme is abundantly expressed and present in numerous tumor cell lines, in which its concentration is often upregulated ubiquitously. GLO1 is a major susceptible gene for autism in an ethnic Chinese population from Taiwan. GLO1 might be involved in the pathophysiology of mood disorders. GLO1 plays a role in the pathophysiology of mood disorders. Overexpression of GLO1 is associated with kidney tumor.

References

Kim N.-S.,et al.J. Biol. Chem. 268:11217-11221(1993).
Ranganathan S.,et al.J. Biol. Chem. 268:5661-5667(1993).
Ridderstroem M.,et al.Biochem. J. 314:463-467(1996).
Ranganathan S.,et al.Gene 240:149-155(1999).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 270.00
Cat# PBV10625r
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