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Human recombinant protein Glyoxalase I
Human Recombinant Glyoxalase I
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q04760 |
|---|---|
| Concentration | 1 |
| Calculated MW | 20.7 kDa (184 aa, 1-184 aa) |
| Gene ID | 2739 |
|---|---|
| Gene Symbol | GLO1 |
| Other Names | Lactoylglutathione lyase, Glx 1, GLO-1 Methylglyoxalase, Aldoketomutase |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | >0.4 units/mg |
| Sequence | MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM |
| Format | Liquid |
| Storage | -80°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GLO1 is involved in the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutathione. GLO1 is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. GLO1 enzyme is abundantly expressed and present in numerous tumor cell lines, in which its concentration is often upregulated ubiquitously. GLO1 is a major susceptible gene for autism in an ethnic Chinese population from Taiwan. GLO1 might be involved in the pathophysiology of mood disorders. GLO1 plays a role in the pathophysiology of mood disorders. Overexpression of GLO1 is associated with kidney tumor.
References
Kim N.-S.,et al.J. Biol. Chem. 268:11217-11221(1993).
Ranganathan S.,et al.J. Biol. Chem. 268:5661-5667(1993).
Ridderstroem M.,et al.Biochem. J. 314:463-467(1996).
Ranganathan S.,et al.Gene 240:149-155(1999).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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