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Human recombinant protein ADA

Human Recombinant ADA

     
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Product info
Primary Accession P00813
Concentration 0.5
Calculated MW 42.9 kDa (383 aa, 1-363 aa + NT His Tag)
Additional Info
Gene ID 100
Gene Symbol ADA
Other Names Adenosine deaminase, Adenosine aminohydrolase, ADA1.
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE; ≥85%
Assay2&Purity2 N/A;
Recombinant Yes
Results >25 units/mg
Sequence MGSSHHHHHH SSGLVPRGSH MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA YQEAVKSGIH RTVHAGEVGS AEVVKEAVDI LKTERLGHGY HTLEDQALYN RLRQENMHFE ICPWSSYLTG AWKPDTEHAV IRLKNDQANY SLNTDDPLIF KSTLDTDYQM TKRDMGFTEE EFKRLNINAA KSSFLPEDEK RELLDLLYKA YGMPPSASAG QNL
Format Liquid
Storage -80°C; 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol.
Citations (0)

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Background

ADA, also known as adenosine deaminase, catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. This protein plays an important role in purine metabolism and in adenosine homeostasis. ADA acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte epithelial cell adhesion.

References

Daddona P.E.,et al.J. Biol. Chem. 259:12101-12106(1984).
Wiginton D.A.,et al.Nucleic Acids Res. 12:2439-2446(1984).
Valerio D.,et al.EMBO J. 4:437-443(1985).
Wiginton D.A.,et al.Biochemistry 25:8234-8244(1986).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 325.00
Cat# PBV10629r-50
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