|Calculated MW||13 kDa, non-disulfide bonded homodimer, non-glycosylated.|
|Other Names||Beta Polypeptide, NGF, NGFB, HSAN5, Beta-NGF, MGC161426, MGC161428|
|Source||Human cell expressed|
|Results||1.5 to 8 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
NGF-beta has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. The presence of beta NGF in immune cells and endocrine cells as well as in the CNS limbic areas suggests that beta NGF may function as an intracellular messenger to regulate the body’s response to stress. This product is produced in a human cell expression system with serum-free, chemically defined media.
Ullrich A.,et al.Nature 303:821-825(1983).
Ullrich A.,et al.Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1983).
Borsani G.,et al.Nucleic Acids Res. 18:4020-4020(1990).
Tong Y.,et al.Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1997).
Kitano T.,et al.Mol. Biol. Evol. 21:936-944(2004).
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