|Calculated MW||17 and 27 kDa, monomer, glycosylated|
|Other Names||HBGF4, FGF-4, FGF4, KFGF, HSTF1|
|Source||Human cell expressed|
|Results||0.25 to 1.25 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
FGF4 is involved in mitogenic and cell survival activities and takes part in a range of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF4 possess oncogenic transforming activity. FGF4 and FGF3, oncogenic growth factors are localized on chromosome 11. Co-amplification of both factors was found in several kinds of human tumors. FGF4 functions in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Human FGF-4 shares high homology and cross-reactivity with the mouse protein.
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Delli-Bovi P.,et al.Cell 50:729-737(1987).
Ornitz D.M.,et al.J. Biol. Chem. 271:15292-15297(1996).
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