|Calculated MW||26 and 30 kDa, monomer, glycosylated|
|Other Names||IFN-b2, B cell differentiation factor, BCDF, BSF-2, HPGF, HSF, MGI-2, B-cell stimulatory factor 2, Interferon beta-2, Hybridoma growth factor, CTL differentiation factor, CDF, IL-6, HGF.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||0.2 to 1 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
Il-6 is a cytokine with a wide variety of biological functions. It is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It plays an essential role in the final differentiation of b-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation and in hepatocytes it induces acute phase reactants.
Hirano T.,et al.Nature 324:73-76(1986).
Yasukawa K.,et al.EMBO J. 6:2939-2945(1987).
May L.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:8957-8961(1986).
Zilberstein A.,et al.EMBO J. 5:2529-2537(1986).
Brakenhoff J.P.J.,et al.J. Immunol. 139:4116-4121(1987).
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