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Human CellExp Noggin, Human recombinant protein

Human Cellexp Human Recombinant Noggin

Product info
Primary Accession Q13253
Calculated MW 65 kDa, homodimer, glycosylated
Additional Info
Gene ID 9241
Gene Symbol NOG
Other Names SYM1, SYNS1, NOG.
Gene Source Human
Source Human 293 cell expressed
Assay&Purity SDS-PAGE; > 95%
Assay2&Purity2 N/A;
Recombinant Yes
Results 20 to 100 ng/ml
Application Notes Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Format Lyophilized
Storage -80°C; Lyophilized in PBS.
Citations (0)

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Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.


Valenzuela D.M.,et al.J. Neurosci. 15:6077-6084(1995).
Groppe J.,et al.Nature 420:636-642(2002).
Gong Y.,et al.Nat. Genet. 21:302-304(1999).
Takahashi T.,et al.Clin. Genet. 60:447-451(2001).
Dixon M.E.,et al.Genet. Med. 3:349-353(2001).

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$ 230.00
$ 940.00
Cat# PBV10706r
(40 western blots)
Availability: 5-7days
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