|Calculated MW||35, 40 and 45 kDa, homodimer, glycosylated|
|Other Names||Glioma-derived growth factor, GDGF, Osteosarcoma-derived Growth Factor, ODGF, PDGF-AA, PDGF-1.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||200 to 1000 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 10 mM AcOH.|
|Storage||-80°C; Lyophilized from a solution of 10 mM AcOH.|
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Provided below are standard protocols that you may find useful for product applications.
PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB.
Bonthron D.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:1492-1496(1988).
Rorsman F.,et al.Mol. Cell. Biol. 8:571-577(1988).
Betsholtz C.,et al.Nature 320:695-699(1986).
Hoppe J.,et al.FEBS Lett. 223:243-246(1987).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
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