|Calculated MW||35, 40 and 45 kDa, homodimer, glycosylated|
|Other Names||Glioma-derived growth factor, GDGF, Osteosarcoma-derived Growth Factor, ODGF, PDGF-AA, PDGF-1.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||200 to 1000 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 10 mM AcOH.|
|Storage||-80°C; Lyophilized from a solution of 10 mM AcOH.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB.
Bonthron D.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:1492-1496(1988).
Rorsman F.,et al.Mol. Cell. Biol. 8:571-577(1988).
Betsholtz C.,et al.Nature 320:695-699(1986).
Hoppe J.,et al.FEBS Lett. 223:243-246(1987).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
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